Adhesion-GPCRs : structure to function

Auteur :
Yona Simon
Yona Simon, ed. scientifique
Stacey Martin, ed. scientifique
Publication :
Boston, MA : Springer US : Springer e-books, 2010
Collection :
Advances in experimental medicine and biology
Advances in experimental medicine and biology (Print)
Résumé :
Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation
Contenu :
The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution 7TM-Cadherins: Developmental Roles and Future Challenges Latrophilin Signalling in Tissue Polarity and Morphogenesis GPS Proteolytic Cleavage of Adhesion-GPCRs The Latrophilins, Split-Personality Receptors Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals Adhesion-GPCRs in the CNS GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression Adhesion-GPCRs in Tumorigenesis Immunity and Adhesion-GPCRs CD97 in Leukocyte Trafficking The Role of CD97 in Regulating Adaptive T-Cell Responses F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation Signal Transduction Mediated through Adhesion-GPCRs Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 Adhesion-GPCRs in the Male Reproductive Tract
Disponible en ligne
Langue :
Type de document :
Ressource électronique
Thèmes :
Antigènes CD
Récepteurs couplés aux protéines G
Biomedicine general
Molecular Medicine